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One reason why the ketogenic diet is one of the best diets for bodybuilders is that it tends to increase human growth hormone levels due to how it mimics fasting with carbohydrate restrictionand a low protein intake. While ketones are known as being anabolic, growth hormone has been associated with more than its "Anabolic" counterpart. The hormones that influence growth hormone production, such as growth hormone receptor-2 and growth hormone-binding protein-7, are very common in bodybuilders and athletes. Growth hormone-binding protein-7 is often associated with the growth spurt and is present in almost all cell-bound testosterone and androstenedione. Testosterone that has been bound with growth hormone has been reported to increase a rise in lean mass and strength. In addition, growth hormone has been reported to reduce the effects of a number of diseases including insulin resistance and atherosclerosis.Another example of how ketones can effect hormones has been the effect ketones have on the endocannabinoid system. The endocannabinoid system is responsible for many of the effects of marijuana including the mood-altering effects and its ability to relieve pain. The endocannabinoid system seems to be largely activated during physical exercise. The increased endocannabinoid activity of ketones may be related to a lower sensitivity of cells to endocannabinoids, a lack of their receptors, or possibly due to decreased uptake. This decrease in endocannabinoid activity in the mitochondria may be related to the reduced levels of endocannabinoids on the mitochondria as well as the increased amount of ATP produced and stored in the mitochondria or other factors including an increase in the amount the endocannabinoid system is able to activate from glucose-6-phosphate or reduced levels of the anandamide anandamide metabolite and subsequent a reduced ability to transport fatty acids into cells. The increased production of acetyl-CoA in the mitochondria may contribute to a reduced amount of the fatty acid anandamide in cell membranes.Other effects of ketosisKetones can have several effects after a calorie restriction. Increased blood sugar has been reported after a 1-day fast and following a 2-day fast by both healthy human subjects and diabetic subjects. Other effects include increased blood pressure, decreased cortisol concentrations, decreased appetite while eating, and decreased body fat. Increased glucose uptake after the two-day fast and following a diet high in carbohydrates has been reported after 2-day fasting in animals.Ketones are also reported to increase levels of several ketone bodies including ketone hydroxylaseRelated Article: